摘要
Abstract
Objective To investigate the association of the metabolic syndrome with urinary albumin excretion and glomerular filtration rate. Methods From October 2008 to March 2010,452 subjects without diabetes mellitus, glomerular disease and medication intaking was enrolled in this study. (125 female,327 male,mean age was 52±1. 9 years and mean BMI was 23. 8 ±0. 8 kg/m2). Subjects was divided into metabolic syndrome group (n=58,mail/female=44/14) ,and control group (n= 394,mail/female=282/112) according to IDF (International Association of endocrine surgeons) standard. Data of smoking history,waistline,blood pressure,lipids,fasting glucose,serum creatinine,glomerular filtration rate (GFR) and urinary albumin was collect and analyzed. Results Urinary albumin excretion increased significantly ( P<0. 05) and glomerular filtration rate showed insignificant decrease (P<0. 05) in patients with metabolic syndrome. Of all the 5 metabolic syndrome components and other clinical characteristics, systolic blood pressure was the independent determinant for the urinary protein excretion and glomerular filtration rate(OR=l. 13,95% CI:1. 11 — 1. 15,P<0. 01). Conclusion Metabolic syndrome could be a clinical syndrome which is associated with vascular dysfunction. But it showed a negative relationship with glomerular filtration rate in the people without diabetes, glomerular disease and medication consumption.关键词
代谢综合征/尿微量清蛋白/肾小球滤过率Key words
metabolic syndrome/urinary albumin/glomerular filtration rate分类
医药卫生
