陕西医学杂志2012，Vol.41Issue(9)：1110-1111,1114,3.
氟比洛芬酯对炎症痛大鼠血儿茶酚胺及β-内啡肽水平的影响
Effect of Flurbiprofen axetil on the plasma catecholamine and β-EP level in the inflammatory painful model formalin-induced rats
摘要
Abstract
Objective: To explore the analgesic mechanism of the Flurbiprofen axetil . Methods:Rats were randomized to either Ⅰ of Ⅳ groups (n = 6 rats for each group) : Group I received a intraperitoneal injection of 2 ml of normal saline solution 10min prior to intraplantar injection of 0. 1 ml of 5% formalin solution; Group II received a intraperitoneal injection of 2 ml of 50mg/kg flurbiprofen axetil while intraplantar injection of 0. 1 ml of 5% formalin solution, Group Ⅲ 、 Ⅳ received a intraperitoneal injection of 25,50mg/kg 2 ml of flurbiprofen axetil respectively prior to intraplantar injection of 0. 1 ml of 5% formalin solution. The levels of plasma E,NE and β-KP were measured respectively. Results :Compared to group I , the level of plasma E,NE were significantly less in those of group Ⅱ、Ⅲ、Ⅳ,while that of group IV were less than group HI significantly (P <0. 05) ; plasma β-EP was significantly more in those of group Ⅱ、Ⅲ、Ⅳ, while that of group Ⅳ were more than group HI significantly (all P < 0. 05) . Conclusion:The analgesic of Flurbiprofen axetil also probably superimposing on the effect of peripherd and central nervous system.关键词
炎症/药物疗法/炎症/血液/氟比洛芬/治疗应用/儿茶酚胺类/代谢/β-内啡肽/代谢/镇痛/动物,实验/大鼠Key words
Inflammation/drug therapy/ Inflammation/blood/ Flurbiprofen/therapeutic use/ Catecholamines/metabolism/Beta-endorphin/metabolism/Analgesia/Animals, laboratory/Rats分类
医药卫生引用本文复制引用
刘颖,赵玲,刘西娟,杨菊花,王智..氟比洛芬酯对炎症痛大鼠血儿茶酚胺及β-内啡肽水平的影响[J].陕西医学杂志,2012,41(9):1110-1111,1114,3.基金项目
陕西省科学技术研究发展计划项目基金资助 (2010K15-08) （2010K15-08）
