实用妇产科杂志2012，Vol.28Issue(6)：497-500,4.
晚期糖基化终产物水平及其受体的表达与妊娠期糖尿病围生儿结局关系的研究
Relationship between Advanced Glycation End Products and Perinatal Outcome of Gestational Diabetes Patients
摘要
Abstract
Objective:To explore the relationship between serum advanced glycation end products (AGEs) level in gestation diabetic(GDM) patients and their perinatal outcomes, and to observe the RAGE protein expression in placenta. Methods: Recruit 100 cases pregnant women diagnosed with GDM between 24-28 weeks gestational age as the observation group, and another 50 cases of normal pregnant women of corresponding age as the study control. The blood samples of GDM patients was extracted ,blood glucose, HbAic. AGE was determined. The placentas were cryopreservated immediately after delivery for the analysis of tissue expression of RAGE protein. And the maternal and infant clinical information were collected, The patients were also divided into normal perinatal group and abnormal perinatal group according to their perinatal outcomes. Results:①GDM groups had higher serum AGEs levels and fasting blood glucose compared to the control group (P<0. 05). ②The same GDM in late pregnancy after intervention treatment, blood glucose was significantly lower HbA1 c and the control group the difference was not statistically significant (P >0. 05), but the level of serum AGEs remained higher. ③Abnormal perinatal outcome in GDM had significantly higher maternal serum AGEs level than that in controls with normal perinatal outcome( P<0.05) . ④Logistic regression analysis showed that AGEs was a predictor of adverse perinatal outcome in GDM( OR =6.197,P< 0.001, 95% Cl: 2.514 ~ 15.453). ⑤The RAGE protein expression in the placenta was also higher in the abnormal perinatal group than that in normal perinatal group and control group. Conclusions: High serum AGEs is a negative factor for the GDM perinatal outcome, High levels of AGEs can be used as a abnormal perinatal outcome predictor in GDM patients.关键词
晚期糖基化终产物/妊娠期糖尿病/胎盘/围生儿/预测Key words
Advanced glycation end product/ Gestation diabetes mellitus/ Placenta/ Perinatal/ Predictors分类
医药卫生引用本文复制引用
汤栩文,林斯,谢晓斌..晚期糖基化终产物水平及其受体的表达与妊娠期糖尿病围生儿结局关系的研究[J].实用妇产科杂志,2012,28(6):497-500,4.基金项目
2011年度广州市卫生局医药卫生科技项目(编号:201102A213037) （编号:201102A213037）
