实用肿瘤杂志2012，Vol.27Issue(4)：332-337,6.
肝癌肝移植术后骨转移的放射治疗及其对预后的影响
Radiotherapy for bone metastases of hepatocellular carcinoma after liver transplantation
何健 1曾昭冲 1杨平1
作者信息
- 1. 复旦大学附属中山医院放疗科,上海200032
- 折叠
摘要
Abstract
Objective To evaluate the efficacy of radiotherapy (RT) for patients with bone metastases (BM) from hepatocellular carcinoma (HCC) after liver transplantation (LT). Methods Among 853 patients with HCC and liver transplantation, 30 had bone metastases during the follow-up and received external-beam radiotherapy (EBRT). EBRT was performed with a dose of 8 ~60 Gy (median dose:40 Gy) based on CT,MRI,ECT findings and focused on bone metastasis lesions with serious pain or high risk of pathologic fracture. The survival of patients was analyzed with Kaplan-Meier curves, log-rank tests, and multivariate COX regression analysis (backward wald). Results The 1-,2-year survival rates and median survival since BM were 39. 7% ,24. 4% and 8. 6 months, respectively. 96.7% patients got pain relief after EBRT. There was no significant difference in pain relief in the dose range of 30~56 Gy (P=0.670). Conclusion EBRT is an effective treatment to improve the quality of survival for patients with bone metastases from hepatocellular cell carcinoma after liver transplantation.关键词
肝肿瘤/外科学/肝移植/癌,肝细胞/治疗/骨肿瘤/继发性/骨肿瘤/放射疗法/存活率/回顾性研究Key words
liver neoplasms/surgery/ liver transplantation/bone neoplasms/secondary/ bone neoplasms/ radiotherapy/ survival rate/ retrospective studies分类
医药卫生引用本文复制引用
何健,曾昭冲,杨平..肝癌肝移植术后骨转移的放射治疗及其对预后的影响[J].实用肿瘤杂志,2012,27(4):332-337,6.
