摘要
Abstract
Objective To evaluate the efficacy of three-dimensional conformal radiotherapy (3D-CRT) combined with temozolomide (TMZ) in treatment of high-grade glioma (HGG). Methods Sixty five postoperative patients with high-grade glioma were randomly divided into 3D-CRT with TMZ group (combination group) and 3D-CRT alone group (control group). There were 35 cases in combination group, including 21 cases with grade Ⅲ ,14 cases with grade IV; 30 cases in control group, including 18 cases with grade Ⅲ and 12 cases with grade IV. Three-dimensional conformal radiation therapy for brain was given at DT 60 Gy/30 f for 42 d. Patients in combination group also received concomitant 75 mg/m2/d TMZ until the end of radiotherapy, followed by 6 courses of adjuvant chemotherapy with 150~200 mg/(m2 ? d) TMZ × 5 d: this was repeated every 28 d. The control group followed the same radiotherapy plan as described above. Results For combination group,the 1-,2- and 3-y survival rates were 88.6% (31/35) ,45.7% (16/35) and 25.7% (9/35) respectively,with a median survival time of 20 months. For control group,the 1-,2- and 3-y survival rates were 43.3% (13/30) ,16. 7% (5/30) ,and 6. 7% (2/30) respectively, with a median survival time of 12 months (all P<0.05). Hematological toxicity and symptoms of radiation-induced brain injury were tolerable in both groups. Conclusion 3D-CRT combined with TMZ chemotherapy improves the survival rates of high grade malignant glioma compared to 3D-CRT alone.关键词
脑肿瘤/放射疗法/脑肿瘤/药物疗法/神经胶质瘤/放射疗法/神经胶质瘤/药物疗法/放射疗法,适形/方法/存活率Key words
brain neoplasms/radiotherapy/ brain neoplasms/drug therapy/ glioma/radiotherapy/ glioma/ drug therapy/ radiotherapy, conformal/ (methods) / survival rate分类
医药卫生
