生殖医学杂志2012，Vol.21Issue(4)：303-307,5.DOI:10.3969/j.issn.1004-3845.2012.04.001
雌激素受体α基因多态性与中国妇女特发性卵巢早衰的相关性研究
Estrogen receptor α gene polymorphisms associated with idiopathic premature ovarian failure in Chinese women
刘丽鹏 1谭容容 1崔毓桂 1刘嘉茵 1吴洁1
作者信息
- 1. 南京医科大学第一附属医院妇产科,南京210029
- 折叠
摘要
Abstract
Objective: To evaluate the relationship between estrogen receptor a gene (ERa) polymorphisms and idiopathic premature ovarian failure (POF) in Chinese women.
Methods; A total of 155 Chinese women with idiopathic POF and 155 healthy controls were enrolled. All subjects were analyzed for the PvuII and Xbal loci of the ERa gene using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP).
Results; Among idiopathic POF patients, the frequency distribution of three kinds of ERa PvuII genotypes, i.e. pp, Pp and PP, were 38. 1% (59/155), 47. 7% (74/155) and 14. 2% (22/155) respectively, while the prevalence of ERa Xbal genotypes was xx 61. 3% (95/155), Xx 35. 5% (55/155) and XX 3. 2% (5/155) respectively. In addition, the allele frequencies of P and X in POF patients were significantly higher than those of controls (P<0. 05). Moreover, our date showed that women with the P-X haplotype might have 1. 66 times higher risk of POF than women with the p-x haplotype (P<0. 05).
Conclusions: The data suggested that the PvuII and Xbal polymorphisms of ESRlgene were associated with idiopathic POF. P allele, X allele and P-X haplotype might increase the risk of developing POF in Chinese women.
关键词
卵巢早衰/雌激素受体/基因多态性Key words
Premature ovarian failure/ Estrogen receptor/ Gene polymorphism 引用本文复制引用
刘丽鹏,谭容容,崔毓桂,刘嘉茵,吴洁..雌激素受体α基因多态性与中国妇女特发性卵巢早衰的相关性研究[J].生殖医学杂志,2012,21(4):303-307,5.
