西安交通大学学报（医学版）2012，Vol.33Issue(4)：435-438,4.
乙醇致家兔急性心衰模型的建立
Establishment of alcohol-induced acute heart failure model in rabbits
摘要
Abstract
To establish an acute heart failure model induced by alcohol in rabbits. Methods After rabbits were anesthetized and fixed, femoral artery intubation was used for blood pressure (BP) measurement; left ventricle intubation via carotid was used to detect left ventricular systolic pressure (LVSP), left ventricular end diastolic pressure (LVEDP) and ± dp/dt max. Electrocardiogram was recorded through subcutaneous needle electrode. Acute heart failure model was induced by intravenous injection of alcohol (250 mL/L, 1.0 mL/min) at a constant speed. Hearts were harvested after that and analyzed by histological hematoxylin-eosin staining. Results Compared with the normal hemodynamic indexes before model establishment, the SBP, DBP, MBP, LVSP and ± dp/dt max decreased ( P <0.05). Electrocardiogram result showed that heart rate decreased (P<0.05), the duration of P wave, P-R interval, ORS and Q-T intervals were prolonged obviously compared to the baselines (P< 0.05). Pathological examination demonstrated that the cardiac muscular tissues of the model were damaged, which was consistent with the pathological manifestation of heart failure. Conclusion Alcohol can be used to induce acute heart failure, which provides a considerable model for investigation of mechanism and therapy of acute alcohol intoxication-induced hear failure.关键词
乙醇/急性心力衰竭/血流动力学/家兔/动物模型Key words
alcohol/ acute heart failure/ hemodynamics/ rabbits animal model分类
医药卫生引用本文复制引用
刘昊琛,邓忠,张忆雯,欧鼎,王冠英,王兴会,陈莉娜..乙醇致家兔急性心衰模型的建立[J].西安交通大学学报（医学版）,2012,33(4):435-438,4.基金项目
国家自然科学青年基金资助项目(No.30901808) （No.30901808）
陕西省科技统筹创新工程计划项目(No.2011KTCL03-20) （No.2011KTCL03-20）
