西北师范大学学报（自然科学版）2012，Vol.48Issue(4)：66-70,5.
羟丙基-β-环糊精对高乌甲素的包合作用及其热力学稳定性
Study on inclusion complex of hydroxypropyl-β-cyclodextrin with lappaconitine and its thermodynamic stability
摘要
Abstract
The equilibrium phase solubility and double reciprocal plot method were used to investigate the inclusion complex of hydroxypropyl-β-cyclodextrin ( HP-β-CD) with lappaconitine ( LA) under different temperature and pH. The molar ratio between HP-β-CD and LA, the apparent stability constants and thermodynamic constants of the inclusion complex were also studied simultaneously. The results showed that HP-β-CD can react with LA forming a 1: 1 host-guest complex under the given temperature, pH and concentration. The equilibrium phase solubility diagram were AL type. The apparent stability constants was 46. 28 L·mnol-1 and the solubilization capacity was 3.61 respectively. The inclusion procedure of HP-β-CD with LA was controlled mainly by endothermic process and driven by entropy. The formation and stability of the inclusion complex could be improved by rising the inclusion temperature appropriately. The solubility of LA is significantly increased by inclusion complex with HP-β-CD.关键词
羟丙基-β-环糊精/高乌甲素/包合物/热力学稳定性Key words
HP-β-CD/ LA/ inclusion complex/ thermodynamic stability分类
医药卫生引用本文复制引用
马君义,张继,李佳佳,邢润苗,黄玉龙..羟丙基-β-环糊精对高乌甲素的包合作用及其热力学稳定性[J].西北师范大学学报（自然科学版）,2012,48(4):66-70,5.基金项目
西北师范大学教学研究项目(2008045B) （2008045B）
西北师范大学大学生学术科研资助金资助项目(2010-083) （2010-083）
