西北师范大学学报（自然科学版）2012，Vol.48Issue(5)：61-66,6.
聚焦微波促进下碳酸二甲酯作甲基化试剂合成甲基取代的2-巯基吡啶并[2,3-d]嘧啶酮
Focused microwave-assisted synthesis of methylated 2-mercapto-7-arylpyrido[2,3-d] pyrimidin-4-(3H)-ones using DMC
摘要
Abstract
The methylation of 5-aryl-2-mercapto-7-arylpyrido[2,3-d] pyrimidin-4-(3H)-ones promoted by MgO and TBAB under focused microwave using dimethyl carbonate as a non-toxic and environmentally friendly methylation reagent is described. The salient features of this method include comparably high yields and short reaction time. This protocol avoids the use of strong bases and highly toxic methylating agents such as methyl halide or dimethyl sulfate.关键词
2-巯基-5,7-二芳基吡啶并[2,3-d]嘧啶-4(3H)-酮/碳酸二甲酯/聚焦微波辐射/甲基化Key words
5-aryl-2-mercapto-7-arylpyrido[2,3-d] pyrimidin-4-(3H)-ones/ dimethyl carbonate/ focused microwave irradiation/ methylation reaction分类
化学化工引用本文复制引用
王喜存,姚轲,梁军灵,张彰,权正军..聚焦微波促进下碳酸二甲酯作甲基化试剂合成甲基取代的2-巯基吡啶并[2,3-d]嘧啶酮[J].西北师范大学学报（自然科学版）,2012,48(5):61-66,6.基金项目
国家自然科学基金资助项目(20902073,21062017) （20902073,21062017）
西北师范大学科学技术创新工程资助项目(NWNU-KJCXGC-03-64,NWNU-LKQN-10-15) （NWNU-KJCXGC-03-64,NWNU-LKQN-10-15）
