新医学2012，Vol.43Issue(6)：362-365,4.DOI:10.3969/g.issn.0253-9802.2012.06.004
阿替普酶静脉溶栓治疗急性脑梗死预后的影响因素分析
Analysis on prognostic predictors of introvenous thrombolysis with alteplase for acute ischemic stroke
王立志 1罗伟良 1李博生1
作者信息
- 1. 广东惠州市中心人民医院神经内科,516001
- 折叠
摘要
Abstract
Objective: To analyze the prognostic risk factors of intravenous thrombolysis with alteplase for acute ischemic stroke. Methods: Forty-six patients of acute ischemic stroke treated with introvenous alteplase were divided into two groups according to modified rankin scale (mRS) score 90 days after treatment MRS score of 0 to 1 was defined as good outcome and mRS score of 2 to 6 as poor outcome. The baseline characteristics were compared between two groups and the prognostic risk factors were analyzed via logistic regression. Results: The morbidity of atrial fibrillation (P = 0. 031), blood glucose level ( P = 0.001), early ischemic changes on CT (P = 0.043), baseline NIHSS score (P=0.001) and time span from stroke onset to the start of treatment (P=0.001) were lower in patients with good outcome (19 cases) than those with poor outcome (27 cases). Logistic regression analysis showed that high baseline NIHSS score, long time span from stroke onset to the start of treatment and high blood glucose were related to poor outcome independently. Conclusions: The baseline NIHSS score, time span from stroke onset to the start of treatment, level of blood glucose are independent prognostic risk factors of introvenous thrombolysis with alteplase for acute ischemic stroke.
关键词
阿替普酶/静脉溶栓/脑梗死/预后Key words
Alteplase/ Introvenous thrombolysis/ Ischemic stroke/ Prognosis引用本文复制引用
王立志,罗伟良,李博生..阿替普酶静脉溶栓治疗急性脑梗死预后的影响因素分析[J].新医学,2012,43(6):362-365,4.
