烟草科技Issue(7)：61-65,5.
NNK和B[a]P在卷烟烟气基质中的联合致突变性
Synergic Mutagenicity of NNK and B[a]P in Matrix of Cigarette Smoke
摘要
Abstract
Taking B[a]P (benzo[a]pyrene)and NNK [4-(methylnitrosamino)-l-(3-pyridyl)-l-butanone] as the target compounds, setting the concentration of cigarette smoke condensate (CSC) at 0 (CK) ,0.005,0.010,0.015, 0.020 mg/mL,that of NNK at 0 (CK),0.005, 0.010, 0.020,0.040 mg/mL and that of B[a]P at 0 (CK),0.00025, 0.00050,0.00075,0.00100 mg/mL, the synergic mutagenicity of the three components was evaluated. The results showed that: 1)CSC, NNK and B[a]P all induced mutation of Salmonella typhimarium strain TA98 and TA100 with obvious dose response. 2)There existed obvious synergism between B[a]P and CSC;high doses of B[a]P and NNK and low doses of CSC and NNK produced a weak additive effect. 3)Under different conditions, the combined effects induced by the three components on TA98 showed weak additive effect. By and large, the unified mutagenicity of NNK and B[a]P in the matrix of cigarette smoke showed the complexity of dose-response,time-response and sequence of action.关键词
卷烟烟气/NNK/B[a]P/联合作用/致突变性Key words
4-(methylnitrosamino)-l-(3-pyridyl)-l-butanone (NNK)/ benzo[a]pyrene (B[a]P)/ Cigarette smoke/ Synergism/ Mutagenicity分类
轻工纺织引用本文复制引用
木潆,潘秀颉,杨陟华,齐绍武,朱茂祥..NNK和B[a]P在卷烟烟气基质中的联合致突变性[J].烟草科技,2012,(7):61-65,5.基金项目
中国烟草总公司科技项目"卷烟危害性指标体系深化研究"(110200801022). （110200801022）
