烟台大学学报（自然科学与工程版）2012，Vol.25Issue(3)：174-179,6.
焦脱镁叶绿酸-a甲酯的20-meso-位氯代反应及其光谱性质
Chlorination of Pyropheophorbide-a at 20-meso-Position and Their Spectral Propcrties
摘要
Abstract
Methyl pyropheophorbide-a 1 is obtained with 49% yield from chlorophyll-a. The process includes removing central magnesium ion and C132-carbomethoxyl group in one-pot method by reflux in acetic acid and methyla-tion in methanol. The chlorination at 20-meso-position of methyl pyropheo-phorbide-a is carried out using hydrogen peroxide/hydrogen chloride or N-chlorosuccinimide (NCS) as chlorinating agent to generate methyl 20-chloropy-ropheophorbide-a in 72% and 82% yield, respectively. As the reaction mechanisms are discussed, the Uv-vis and ' H NMR spectra of chlorophyllous chlorins before and after chlorination are characterized, ascribed and compared. The reasons for structural changes due to chlorination are explained and summarized.关键词
叶绿素-a/焦脱镁叶绿酸-a甲酯/氯代反应/紫外-可见光谱/核磁共振光谱Key words
chlorophyll-a/ methyl pyropheophorbide-a/ chlorination reaction/ ultraviolet-visible spectrophotome-try/ nuclear magnetic resonance spectroscopy分类
化学化工引用本文复制引用
杨泽,王振,刘洋,徐希森,王进军..焦脱镁叶绿酸-a甲酯的20-meso-位氯代反应及其光谱性质[J].烟台大学学报（自然科学与工程版）,2012,25(3):174-179,6.基金项目
国家科技部中匈政府间合作项目(2008年) （2008年）
山东省自然科学基金资助项目(Y2008B49). （Y2008B49）
