医药导报2012，Vol.31Issue(8)：982-985,4.DOI:10.3870/yydb.2012.08.005
半边莲不同提取物镇痛抗炎作用
Experimental Study on Anti-inflammatory and Analgesic Effects of Different Extracts from Chinese Lobelia
摘要
Abstract
Objective To study analgesic and anti-inflammatory effects of different extracts from Chinese lobelia. Methods Water extract and 75% alcohol extract were obtained from Chinese lobelia. Anti-inflammatory effect of Chinese lobelia was studied by using mouse abdominal cavity capillary permeability increase test induced by acetic acid, mouse auricle swelling test induced by xylene, mouse toe swelling test induced by 10% albumen test in mice. Analgesic action of Chinese lobelia was studied by mouse aceticacid-induced twisting test and hot plate test. Results In the same dose, the water extract of Chinese lobelia significantly inhibited the twisting effect induced by acetic acid in the mice (P<0. 01). The extracts of Chinese lobelia increased the threshold of pain in the mice significantly by hot plate test, after the treatment for 1 h or 2 h (P<0. 05 , P<0. 01). The extracts of Chinese lobelia inhibited xylene-induced mouse auricle swelling (P<0. 05). The extracts of Chinese lobelia also significantly inhibited 10% albumen-induced mouse toe swelling, 0. 5h, 1h,2h or 4h after the induced inflammation (P< 0. 05 , P<0. 01). Conclusion Chinese lobelia has obvious analgesic and anti-inflammatory effects.关键词
半边莲/镇痛/抗炎Key words
Chinese lobelia/ Analgesic action /Anti-inflammatiory分类
医药卫生引用本文复制引用
黄礼德,郭立强,潘廷啟,潘喜英,颜祖弟,刘胜利,赵善民,何显教..半边莲不同提取物镇痛抗炎作用[J].医药导报,2012,31(8):982-985,4.基金项目
右江民族医学院2010～2012年度普高学生科研项目(右医科字[2010]9号) （右医科字[2010]9号）
