湖北医药学院学报2012，Vol.31Issue(3)：209-212,4.
牙周病与卒中相关性的病例-对照研究的Meta分析
Association between Periodontal Disease and Stroke: A Meta-analysis of Case-control Studies
李薇 1毛敏 1任昌菊 2刘彩云 1严艳1
作者信息
- 1. 湖北医药学院附属太和医院口腔医学中心,湖北十堰442000
- 2. 湖北医药学院附属太和医院神经内科,湖北十堰442000
- 折叠
摘要
Abstract
Objective To explore the association between periodontal disease and stroke by performing a meta-analysis. Methods Two authors independently searched the PubMed, Embase, CNKI, CBM, Wanfang, and VIP databases to collect the relevant case-control studies up to April 4th, 2012. After quality assessment of included studies and data extraction, a meta-analysis was performed by using the Comprehensive Meta Analysis V2 software, and the level of evidence was evaluated by using the GRADE system. Results Five engb'sh studies met the criterion. Meta-analysis showed that exposure to periodontal disease could obviously increase 3.93 times risk of incident stroke (OR = 3. 94,95 % CI = 2. 64 - 5. 88, P < 0. 001) , the level of evidence was " morderate quality" . Conclusion Current evidences show that periodontal disease is an independent and significant risk fator for stroke. Further studies according to the degrees of periodontal disease and the clinical subtypes of stroke are needed.关键词
牙周病/卒中/Meta分析/GRADE系统Key words
Periodontal disease/Stroke/Meta-analysis/GRADE分类
医药卫生引用本文复制引用
李薇,毛敏,任昌菊,刘彩云,严艳..牙周病与卒中相关性的病例-对照研究的Meta分析[J].湖北医药学院学报,2012,31(3):209-212,4.
