中国动脉硬化杂志2012，Vol.20Issue(5)：407-411,5.
肥大细胞脱颗粒稳定剂对SD大鼠心肌梗死后不良心室重构的影响
The Effects of Mast Cell Stabilizing Compound on Adverse Ventricular Remodeling of Post-Myocardial Infarction in SD Rats
摘要
Abstract
Aim To clarify the effects of the cardiac mast cells on cardiac function after myocardial infarction (MI), and to study the relationship between mast cells and ventricular remodeling after MI in SD rata. Methods MI model was established in male Sprague-Dawley(SD) rats by ligation of left anterior descending coronary artery. The rats were randomly divided into three groups before 5 days of ligation ?sham-operated group( n = 6), MI model group(n = 8) and mast cell stabilizer cromolyn sodium treatment group(n = 7). Before 3 days, after 2 and 4 weeks of ligation, the cardiac function was assessed by Echocardiography. After 4 weeks of treatment, the ratio of left or right ventricular weight and body weight were measured, the change of histopathological were observed, and the density of mast cells were measured. Results As compared with sham-operated group, left ventricular ejection fraction ( EF) in MI model group and treatment group was markedly decreased (P < 0. 01) after 2 weeks of treatment. Although the enlargement of the heart has been going in model group and treatment group, there is no significant difference among these three groups. After 4 weeks of the treatment, the Left ventricular end-diaatolic volume ( EDV) was significantly increased in model group and treatment group more than in sham-operated group(P <0. OS). Compared with MI model group,cromolyn sodium increased EF but not EDV, and decreased left ventricular index (P < 0. 05) and mast cells density( P < 0. 01) in left ventricular subepicardi-al layers of infarted region. The number of mast cells in subepicardial layers had negative correlation with EF, but wasinhibiting the Egr-I, reduce the expression of PAI-1, and then inhibit early thrombosis and neointimal hyperplasiao关键词
心脏肥大细胞/心肌梗死/不良心室重构Key words
Cardiac Mast Cells/Myocardial Infarction/Adverse Ventricular Remodeling分类
医药卫生引用本文复制引用
郭伟,梁远红,靳立军,符永恒,谢至,张梦珍,李寰..肥大细胞脱颗粒稳定剂对SD大鼠心肌梗死后不良心室重构的影响[J].中国动脉硬化杂志,2012,20(5):407-411,5.基金项目
广东省自然科学基金项目(9151601501000007) （9151601501000007）
