中国动脉硬化杂志2012，Vol.20Issue(5)：435-439,5.
牛磺酸抑制高脂合并高同型半胱氨酸血症致兔动脉粥样硬化
Taurine Restraining Atherosclerosis Induced by Hyperlipemia and Hyperhomocysteinemia in Rabbit
摘要
Abstract
Aim To study the role and principle of laurine in inhibiting atherosclerosis induced by hyperlipemia and hyperhomocysteinemia in rabbit. Methods 33 healthy male New Zealand big-eared white rabbits were divided into 3 groups; normal, model and intervention group. Blood was drawn for laboratory test at 0, 2nd, 12tfa week respectively. The rabbits were executed and abdominal aortas were taken out for pathology dyeing at 12th week. Results Ho-mocysteine ( Hey) , high density lipoprotein cholesterol (HDLC) of intervention group had no significant difference in comparison with model group (P > 0.05). However, triglyceride ( TG), total cholesterol (TC), low density lipoprotein cholesterol (LDLC), oxidized low density lipoprotein (ox-LDL) lowering had significant difference (P <0. 05). Atheroma-tous plaques area, endothelium thickness and vascular cell adhesion molecule-1 (VCAM-1) positive cells percentage of intervention group were obviously reduced in comparison with model group (P<0. 05). Conclusion Taurine, as endogenous cell protective substance, may inhibit atherosclerosis through suppressing endothelial hyperplasia, vascular smooth muscle cell ( VSMC) proliferation and migration, reducing hyperlipemia and suppressing oxidation stress rather than lowering hyperhomocysteinemia.关键词
牛磺酸/高脂血癌/高同型半胱氨酸血症/动脉粥样硬化Key words
Taurine/Hyperlipemia/Hyperhomocysteinemia/Atherosclerosis分类
医药卫生引用本文复制引用
袁吉祥,姚成立,马云海,张璞璞..牛磺酸抑制高脂合并高同型半胱氨酸血症致兔动脉粥样硬化[J].中国动脉硬化杂志,2012,20(5):435-439,5.基金项目
银川市科技攻关项目资助(2010028) （2010028）
