中国动脉硬化杂志2012，Vol.20Issue(5)：463-468,6.
内皮型一氧化氮合酶和N5,N10-亚甲基四氢叶酸还原酶基因多态性与苏皖地区汉族人群早发冠心病易感性的相关关系
Correlation Study on Polymorphisms of the Endodermis Nitricoxide Synthase Gene and N5, N10 Methylene Tetrahydrofolate Reductase Gene in Han Patients with Premature Coronary Artery Disease in the Suwan Region
蒋健刚 1刘俊 1陈金国1
作者信息
- 1. 安徽省滁州市第一人民医院,安徽省滁州市 239000
- 折叠
摘要
Abstract
Aim To investigate a potential association of the gene polymorphisms of endodermis nitricoxide syn-thase(eNOS) and N5, N10 methylene tetrahydrofolate reductase (MTHFR) gene with premature coronary artery disease (PCAD). Methods The polymorphisms of gene eNOS and MTHFR were measured by polymerase chain reaction and restriction fragment length polymorphism analysis( PCR-RFLP) in 131 patients with PCAD ( PCAD group)and 131 non-coronary heart disease patients (control group), who were matched in age and sex. Results The frequencies of eNOS G894T gene polymorphism (y2 a 2.072, P = 0. 355) and its T allele (x2 = 0. 727, P = 0. 394) in PCAD group were not significantly different from those in control group. The frequencies of MTHFR C677T gene polymorphism T allele were significantly higher in PCAD group than those in control group(^2 = 16. 339, P = 0.000). The frequencies of the three genotypes (CC, CT and TT) were significantly different between the two groups( x* = 14. 290, P = 0.001). Logistic regression analysis indicated that MTHFR 677C/T TT genotype was an independent risk factor in PCAD( P <0.05). Conclusion The eNOS G894T polymorphism may have no association with the pathogenesis of PCAD in Han patients of Swnan region; the TT genotype of the MTHFR C677T gene may increase the risk of PCAD. The genetic polymorphism of MTHFR gene promoter is associated with the susceptibility to PCAD in Suwan Han nationality.关键词
内皮型一氧化氮合酶/N5,N10-亚甲基四氢叶酸还原酶/基因多态性/早发冠心病Key words
Endodermis Nitricoxide Synthase/N5, N10 Methylene Tetrahydrofolate Reductase/Gene Polymorphism/Premature Coronary Artery Disease分类
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蒋健刚,刘俊,陈金国..内皮型一氧化氮合酶和N5,N10-亚甲基四氢叶酸还原酶基因多态性与苏皖地区汉族人群早发冠心病易感性的相关关系[J].中国动脉硬化杂志,2012,20(5):463-468,6.
