中国动脉硬化杂志2012，Vol.20Issue(5)：472-476,5.
脂蛋白(a)与动脉粥样硬化研究进展
Advances in Relationship Between Lipoprotein(a) and Atherosclerosis
摘要
Abstract
Upoprotein( a) consists of low density lipoprotein (LDL) and the unique constituent apolipoprotein( a). Elevated plasma lipoprotein (a) level is an independent risk factor of atherosclerotic disorders and cardiovascular disease. Upoprotein(a) not only can participate in the formation of atheromatous plaque but also affect the anti-inflammatory mechanism and the balance between procoagulant and anticoagulant agents of the blood vessel wall. Plasma lipoprotein (a) levels which are under strong genetic control can be quite different between individuals. Lipoprotein( a) plasma levels are relatively resistant to many pharmacologic and nonpharmacologic agents, effective and safe approaches to lower Upo-protein(a) plasma level in clinic are still lacking. However, in recent years, researchers have found a few methods to lower lipoprotein(a) level in laboratory, such as antisense oligonucleotides and synthetic peptides, but further researches are needed when use them as new therapic methods. This paper reviewed the recent research advances in relationship between lipoprotein (a) and atherosclerosis.关键词
脂蛋白(a)/载脂蛋白(a)/动脉粥样硬化Key words
Lipoprotein(a)/Apolipoprotein( a)/Atherosclerosis分类
医药卫生引用本文复制引用
杨简..脂蛋白(a)与动脉粥样硬化研究进展[J].中国动脉硬化杂志,2012,20(5):472-476,5.基金项目
国家自然科学基金(81070221)资助 （81070221）
