中国动脉硬化杂志2012，Vol.20Issue(7)：631-634,4.
尼可地尔对冠状动脉慢血流患者冠状动脉贮备功能的影响
Effects of Nicorandil on Coronary Flow Reserve in Patients with Coronary Slow Flow
邹祎 1陈小林 1余泽洪 1汤立军 1冼伟进 1王晓霞 1郑劲松1
作者信息
- 1. 江门市人民医院心内科,广东省江门市529051
- 折叠
摘要
Abstract
Aim To investigate the impact of nicorandil on coronary flow reserve (CFR) in patients with slow coronary flow. Methods A total of 44 patients with coronary slow flow but normal coronary angiography were included in this study, patients were divided into nicorandil group (5 mg/d for 6 months, n =24) and control group (" =20), Doppler coronary flow velocity end Doppler reserve measurement of distal left anterior descending were recorded at rest and adenosine measurement of distal left anterior descending were recorded at rest and adenosine infusion induced hyperemia state, CFR was calculated by the ratio of maximal hyperemia and baseline peak diastolic coronary flow velocity ( HCFV and BCFV) before and after nicorandil treatment. Results 6 months later, compared with control group and nicorandil group before treatment, 6 months nicorandil treatment was associated with no difference of BCFV (26. 37 ±5. 39 cm/a vs 24.72 ±4.35 cm/s, P>0.05; 26. 37 ±5.39 cm/s vs 24.61 ±6.18 cm/s, P>0.05), increased HCFV (73.69 ±9. 84 cm/s vs 55.97 ± 7.62 cm/s, P < 0.05; 73.69 ±9. 84 cm/s vs 51.29 ±9.72 cm/s, P<0.05), and increased CFR (2. 79 ±0.53 vs 1.99 ±0.47, P<0.05; 2. 79 ±0.53 vs 2.08 ±0.44, P<0.05). Conclusion Coronary flow reserve could be significantly improved by nicorandil therapy in patients with coronary slow flow.关键词
冠状动脉慢血流/尼可地尔/冠状动脉贮备功能Key words
Slow Coronary Flow/Nicorandil/Coronary Flow Reserve分类
医药卫生引用本文复制引用
邹祎,陈小林,余泽洪,汤立军,冼伟进,王晓霞,郑劲松..尼可地尔对冠状动脉慢血流患者冠状动脉贮备功能的影响[J].中国动脉硬化杂志,2012,20(7):631-634,4.
