中国肺癌杂志2012，Vol.15Issue(7)：404-408,5.DOI:10.3779/j.issn.1009-3419.2012.07.03
水通道蛋白3在非小细胞肺癌中的表达及与临床病理相关性的研究
Correlation of Aquaporin 3 Expression with the Clinicopathologic Characteristics of Non-small Cell Lung Cancer
摘要
Abstract
Background and objective Lung cancer is a major health problem worldwide. The aim of this study is to investigate aquaporin 3 (AQP3) expression and its relationship with the clinicopathologic characteristics of non-small cell lung cancer (NSCLC). Methods AQP3 expression and the microvascular density (MVD) of tissue samples from 180 cases with NSCLC were detected by immunohistochemistry. Results AQP3 expression was negative in 25 (13.9%), positive in 67 (37.2%), and strongly positive in 88 (48.9%) of the 180 cases, which was significantly higher than that in the normal tissue (P<0.01). A significant correlation was found between AQP3 expression and MVD (P<0.01), whereas a high MVD was found among patients with strongly positive AQP3 expression. Male patients with positive or strongly positive AQP3 expression had significantly higher expression than female patients did (P=0.003). AQP3 expression was more significantly enhanced in ad-enocarcinoma than that in squamous cell carcinoma (P<0.001). Statistical analysis indicated that the positive rate of AQP3 expression in well-differentiated carcinoma was significantly higher than that in poorly differentiated tumors (P<0.001). Lymph node metastasis was positively correlated with high AQP3 expression (P=0.026). Conclusion AQP3 expression was closely correlated with MVD in NSCLC, whereas high MVD was frequently found in tumors with high AQP3 expression. AQP3, as a therapeutic target for inhibiting high AQP3 expression in NSCLC tissues, may weaken cancer cell proliferation, invasion, and metastasis.关键词
肺肿瘤/AQP3/微血管密度/免疫组织化学Key words
Lung neoplasms/ AQP3/ Microvessel density/ Immunohistochemistry分类
医药卫生引用本文复制引用
李白翎,金磊,钟铿,杜大海..水通道蛋白3在非小细胞肺癌中的表达及与临床病理相关性的研究[J].中国肺癌杂志,2012,15(7):404-408,5.基金项目
本研究受上海市科学技术委员会医学引导基金资助项目(No.114119a9300)资助 （No.114119a9300）
