中国肺癌杂志2012，Vol.15Issue(7)：429-434,6.DOI:10.3779/j.issn.1009-3419.2012.07.07
Lung Cancer:MicroRNA and Target Database
Lung Cancer: MicroRNA and Target Database
Challa KIRAN 1Ponnala DEEPIKA1
作者信息
摘要
Abstract
MicroRNAs (miRNAs) are a class of non-coding RNAs that hybridize to mRNAs and induce either translation repression or mRNA cleavage.Recently,it has been reported that miRNAs could possibly play a critical role in cellular processes like regulation of cell growth,differentiation,and apoptosis,emphasizing their role in tumorigenesis.Likewise,several miRNA's are involved in lung cancer tumorigenesis.The present review puts forth a database of human miRNA's involved in lung cancer along with their target genes.It also provides sequences of miRNA's and their chromosomal locations retrieved from different databases like microCosm (218 microRNAs),PhenomiR (293 microRNAs),and mir2Disease (90 microRNAs) and target gene information such as the pathways like cell cycle regulation,angiogenesis,apoptosis etc.Though miRNA's are still to be explored,they hold a promise as therapeutic targets and diagnostic markers of cancer.关键词
Lung neoplasms/ MicroRNAs/ TargetsKey words
Lung neoplasms/ MicroRNAs/ Targets引用本文复制引用
Challa KIRAN,Ponnala DEEPIKA..Lung Cancer:MicroRNA and Target Database[J].中国肺癌杂志,2012,15(7):429-434,6.
