陈重 1廉婕 1潘伟光 1余治健 1马桂红 1邓启文1
作者信息
- 1. 广东医学院附属深圳南山医院,广东深圳518052
- 折叠
摘要
Abstract
Objective To investigate the resistance of clinical bacterial isolates from a hospitals in 2010. Methods Antimicrobial susceptibility of bacterial isolates from inpatients was detected by BD-automatic identification of bacterial analyzer, and data were analyzed with WHONET5. 4 software. Results A total of 2 192 pathogenic strains were isolated from various clinical specimens from January to December, 2010, 67.97% of which was gram-negative bacilli and 32. 03% was gram-positive cocci. 19. 69% of Staphylococcus aureus and 54. 59% of coagulase negative Staphylococcus was methicillin-resistant (MRSA and MRCNS respectively). The resistant rates of methicillin-esistant strains to β-lactams and other antimicrobial agents were much higher than those of methicillin-sensitive strains. The resistant rate of MRSA to sulfamethoxazoLe/trimethoprim, rifampin, tetracycline, and gentamicin was 1. 67%, 41. 54%,44. 62%,and 58. 46%, respectively, the resistant rates of MRCNS to rifampin and tetracycline was 17. 27% and 36.70%, respectively; vancomycin-,teicoplanin- and linezolid-resistant strain was not found. The resistant rates of Enterococcus faecalis to most detected antimicrobial agents were much lower than those of Entero-coccus faecium. One linezolid-resistant Enterococcus faecalis isolate was first reported in this hospital, vancomycin-resistant strain was not found. Extended-spectrum p-lactamase( ESBD-producing strains accounted for 44. 29% of Escherichia coli and 15. 79% of Klebsiella pneiunoniae. Resistant rates of ESBL-producing Enterobacteriaceae strains were higher than non-ESBL-producing Enterobacteriaceae strains. Resistant rate of Pseudomonas aeruginosa to imipenem and meropenem was 26. 73% and 13. 79%, respectively, resistant rate of Acinetabacter spp. (92. 91% were Acinetabacterbaumannii) to above two carbapenems was 31.35% and 27.17%, respectively. Conclusion Bac- terial resistance is on the rise, especially drug resistance of gram-negative bacilli; resistance of Acinetobacter bau-mannii and Pseudomonas aeruginosa to carbapenems is increasing. It is important to use antimicrobial agents rationally, detect pandrug-resistant strains early, and strengthen infection control.关键词
病原菌/抗药性,微生物/微生物敏感性试验/葡萄球菌属/非发酵菌/耐甲氧西林/超广谱β-内酰胺酶Key words
pathogent drug resistance, microbial/ antimicrobial susceptibility testing/ Staphylacoccus spp. i non-fermentative bacteriaimethicillirrresistance/extended-spectrum β-lactamase分类
医药卫生
