中国骨伤2012，Vol.25Issue(5)：364-368,5.DOI:10.3969/j.issn.1003-0034.2012.05.003
全膝关节磁共振成像积分对膝骨关节炎诊断价值的探讨
Study on the diagnostic value of whole-organ magnetic resonance imaging score (WORMS) in knee osteoarthritis
摘要
Abstract
Objective:To explore the diagnostic value of whole-organ magnetic resonance imaging score (WORMS) in knee osteoarthritis (KOA). Methods: From November 2009 to January 2011,70 patients with KOA combined with knee effusion among outpatient and inpalient were analyzed retrospectively. Among the patients, 12 patients were male, 58 patients were female,ranging in age from 46 to 75 years,with a mean age of (59.66?.93) years. The clinical symptoms were evaluated by WOMAC ,lhe imaging of KOA was assessed by K-L score and WORMS,and COMP and CTX- D were measured respectively by EUSA. The correlation analyses and multiple linear regression analysis were studied to determine associations among biomarkers,clinical variables and radiographic findings of knee joints. Results:The average scores of WOMAC and WORMS were (57.50?.20) and (64.54?6.45) respectively. The median of CTX- Q nd COMP were 2.42 ng/ml and 4.56 ng/ml respectively. Grouped by less than the lowest quartile and more than the highest quartile of WORMS,COMP was significantly different (fc2.04,P=0.039) Tbut there was no significant difference in CTX- II (Z=0.79.P=0.427). WORMS were positively correlated with WOMAC and K-L score (r=0.777,P<0.01 ;r=0.716,P<0.01;respectively); WOMAC was also positively correlated with K-L score (r=0.692 ,P<0.0\). WORMS's cartilage,osteophytes and synovitis were positively correlated with WOMAC,K-L score and COMP respectively (r=0.771 ,P<0.01; r=0.509,P<0.01 :r=0.9l7.P<0.01). It was determined by stepwise regression that the KOA was mainly affected by WORMS,K-L score (P=0.015.P=0.025 respectively)when WOMAC as a dependent variable, age, gender, K-L score .WORMS,COMP and CTX - II as independent variables (F=20.327, P<Q.Q I). Con. elusion: WORMS has a better reference value for diagnosis of KOA. The expression of COMP is high in the synovial fluid when WOK MS at the high point. The clinical symptoms of knee osteoarthritis are mainly affected by WORMS and K-L score.关键词
骨关节炎,膝/磁共振成像/诊断/软骨寡聚基质蛋白/Ⅱ胶原羟基端交联肽Key words
Osteoarthritis.knee/Magnetic resonance imaging) Diagnosis/Cartilage oligomeric matrix protein/C-terminal crosslinking telopeptide of type II collagen引用本文复制引用
王学宗,郑昱新,曹月龙,顾新丰,韦宋谱,高宁阳,刘婷,庞坚,詹红生..全膝关节磁共振成像积分对膝骨关节炎诊断价值的探讨[J].中国骨伤,2012,25(5):364-368,5.基金项目
“中医骨伤科学”国家重点学科建设项目(编号:100508) （编号:100508）
国家自然基金资助项目(编号:81072830) （编号:81072830）
上海市教委创新项目(编号:11YZ64):上海市教委资助项目(编号:08cz025) （编号:11YZ64）
