黄芩素对星形细胞瘤SHG-44细胞增殖、侵袭迁移的影响OACSCDCSTPCD
Influence on cell proliferation and invasiveness of human astrocytic glioma cell line SHG-44 by baicalein
目的:观察黄芩素干预人星形细胞瘤SHG-44细胞株后,肿瘤细胞形态、增殖、凋亡、细胞周期以及运动侵袭能力的变化.方法:以体外培养的人星形细胞瘤SHG-44细胞为研究对象,用黄芩素干预后,显微镜观察细胞形态变化,MTT法观察细胞增殖,流式细胞术分析细胞周期,侵袭小室实验观察细胞侵袭力改变.结果:黄芩素对SHG-44细胞增殖的抑制作用随时间的延长和药物浓度的增加,抑制作用逐渐增强,有明显的时间和剂量依赖性;随黄芩素浓度增加,凋亡率增高,差异有统计学意…查看全部>>
AIM: To investigate the influence on cell proliferation, apoptosis, cell cycle and cell invasiveness after human astrocytic glioma cell line SHG-44 were treated by baicalein with the valious concentrations. METHODS: Human astrocytic glioma cell line SHG-44 were cultured in vitro and treated in various concentrations of baicalein, then MTT method, flow cytometer (FCM) analysis, transwell assay and Western Blot were applied to measure cell growth, cell cycle a…查看全部>>
毛捷;盛莉莉;徐善水;王宣之
皖南医学院弋矶山医院神经外科,芜湖241001,安徽皖南医学院弋矶山医院肿瘤科,芜湖241001,安徽皖南医学院弋矶山医院神经外科,芜湖241001,安徽皖南医学院弋矶山医院神经外科,芜湖241001,安徽
医药卫生
黄芩素SHG-44细胞细胞增殖细胞周期侵袭迁移
BaicaleinSHG-44 cell Proliferation Cell cycle Invasiveness
《中国临床药理学与治疗学》 2012 (7)
750-754,5
安徽省中医药研究课题项目资助(2009ZY40)
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