中国临床药理学与治疗学2012，Vol.17Issue(7)：755-760,6.
临床常用尼群地平片在大鼠体内药代动力学比较研究
Pharmacokinetics of different nitrendipine tablets in rats
摘要
Abstract
AIM: To study the pharmacokinetics of different nitrendipine tablets in rats. METHODS: An LC-MS method was established for the detection of nitrendipine in plasma after a single oral dose of 50 mg/kg nitrendipine tablets. Pharmacokinetics parameters were calculated by DAS 3. 0 data-processing 'system. RESULTS: Determination results of the three bulk drug manufactures indicated that nitrendipine form IV had a higher absorption and bioavail-ability than nitrendipine form 1 which was commonly used. Pharmacokinetic parameters of the 16 products selected randomly from different industries were different after a single dose of 50 mg/kg. Maximum differences of Cmax, ￡max, t1/2, AUC(0-t) came up to 2.5, 24.4, 4.5 and 1.6 times. CONCLUSION: There are differences a-mong the pharmacokinetics of different nitrendipine tablets in rats. Crystal form is a principal element leading to the discrepancies.关键词
尼群地平/LC-MS/晶型/药代动力学/生物利用度Key words
Nitrendipine/ LC-MS/ Crystal form/ Pharmacokinetics/ Bioavailability分类
医药卫生引用本文复制引用
孙加琳,宋俊科,邢程,吕扬,杜冠华..临床常用尼群地平片在大鼠体内药代动力学比较研究[J].中国临床药理学与治疗学,2012,17(7):755-760,6.基金项目
中国药典委员会国家药品标准提同研究项目“药典品种晶型检测分析方法的建立(1680) （1680）
卫生部公益性行业科研专项(200802041,200902008) （200802041,200902008）
