中国临床药理学与治疗学2012，Vol.17Issue(7)：802-805,4.
呼出气冷凝液白三烯、8异前列腺素、硝酸盐/亚硝酸盐检测在哮喘中的应用及孟鲁司特对炎症指标的影响
Value of leukotrienes C4, 8-isoprostane, nitrite/nitrate in exhaled breath condensate and the effect of montelukast on inflammatory factors in asthma
摘要
Abstract
AIM: To investigate the levels of leukotrienes C4 ( LTC4 ), 8-isoprostane, nitrite / nitrate(NO2/NO3) in exhaled breath condensate of patients with asthma and the effect of inflammatory factors after montelukast treatment. METHODS: 30 patients with asthma were enrolled. They were given 10 mg montelukast once each night for one month. Before starting therapy and one month later, the levels of LTC4, 8-isoprostane, NO2/NO3 in exhaled breath condensate were measured. RESULTS: The levels of LTC4(55 + 17) ng/mL, 8-isoprostane (13 + 9) ng/mL, and NO2/NO3 (4.2 + 1.2) ng/mL were significantly higher in the asthma group than those in the control group (17 + 17) ,(7 + 6) ,(3. 2 + 0. 6) ng/mL(P<0.01). The levels of LTC4 (55 + 17) ng/mL in patients with asthma before treatment was significantly higer than those in patients after treatment ( 38 + 14) ng/mL(P<0. 01). Before and after treatment, the levels of 8-isoprostane,NO2/NO3 were (13 + 9 ), ( 11 + 6), (4.2 + 1.2), (4. 1 + 1.4) ng/mL; and there were no significant differences ( P > 0. 05). CONCLUSION: Detecting the LTC4, 8-isoprostane and NO2/NO3 in EBC can be used to monitor asthmatic airway inflammation, which are convenient, noninvasive and safe. Montelukast can decrease the level of LTC4 , which is an effective anti-inflammatory a-gent.关键词
呼出气冷凝液/半胱氨酰白三烯C4/8异前列腺素/硝酸盐/亚硝酸盐/孟鲁司特/支气管哮喘Key words
Exhaled breath condensate/ Leukotrienes C4/ 8-isoprostane/ Nitrite/Nitrate/Montelukasl/ Bronchial asthma分类
医药卫生引用本文复制引用
沈巨信,秦娥,李明晖,孙健,周国忠..呼出气冷凝液白三烯、8异前列腺素、硝酸盐/亚硝酸盐检测在哮喘中的应用及孟鲁司特对炎症指标的影响[J].中国临床药理学与治疗学,2012,17(7):802-805,4.基金项目
绍兴市科技局基金项目(2009A33028) （2009A33028）
