摘要
Abstract
AIM: To compare the therapy effect of inhalation of budesonide suspension with oral montelukast in cough variant asthma ( CVA ) of children.. METHODS: 118 cases of CVA were divided into group A(n = 40) , who were used air compression pump inhalation of budesonide suspension; group B(n = 40), who were taken orally montelukast; group C(n = 38) , who were given loratadine by oral administration . Each group of children were done obser-
vation diary every day, recorded the cough,asthma and medication from day to night, followed up once a week in the treatment of 4 weeks, followed up 1-2 times once month after symptom controlled, telephone followed up during the period. If appeared asthma, outpatient was received follow-up. During the follow-up period, three groups were recorded respectively cough symptoms in day and night after treatment with 1, 2, 3, 4, 8, 12 week and done total scores.
After 6 months of treatment, we assessed the control condition of asthma. Continue to follow-up 18 months, we observed the recurrence of patients within 2 years and the numbers of wheezing episode and changed into typical asthma (CA) of three groups within 2 years, and recorded the adverse reaction during the treatment. RESULTS: The valid control rates of three groups were 97. 5% , 95%, 18.4%, respectively. Compared with group C, the efficacy had significant difference in group A, group B (X2 = 16.004, P < 0. 05). There was no significant difference between group A and group B ( X2 = 1.946, P>0.05). Compared with before treatment, the total scores was decreased in the treatment of 1, 2. 3, 4 week in group A, group B; In the treatment of 2, 3 week, cough score of group A was decreased obviously than that in
group B, the difference was statistically significant (P<0. 05); Three groups after treatment, the number of CVA recurrence and wheezing in group A,B was less than that in group C , and relapse rate of group A was 7. 5% , wheezing ratio was 10%, while in group B were 25%, 35% (X2 = 8.467. P<0. 05). CONCLUSION: Compare with take orally montelukast, compress aerosol inhalation budesonide can anesis clinical symptoms better and faster, reduce the recurrence of CVA, effective prevent into typical asthma, and the long-term efficacy is superior to oral montelukast.关键词
儿童/咳嗽变异性哮喘/布地奈德/孟鲁司特Key words
Children/ Cough variant asthma/ Budesonide/ Montelukast分类
医药卫生
