中国临床药理学与治疗学2012，Vol.17Issue(7)：820-827,8.
CYP450氧化还原酶的药物基因组学研究进展
Advances in pharmacogenomics of cytochrome P450 oxidoreductase
摘要
Abstract
The redox reaction of the cytochrome P450 enzymes ( CYP) are important physiological and biochemical reactions in the human body, involved in the metabolism of endogenous and exogenous compounds and steroids synthesis. POR (cytochrome P450 oxidoreductase) is the only electron donor for all the hepatic microsomal CYP enzymes. Not only acts as an electron donor involved in drug metabolism mediated by CYP enzymes, POR also directly induces the transformation and metabolism of some anti-tumor precursors. Therefore POR plays an important role in drug metabolism. The gene encoding human POR is highly polymorphic, which is of great clinical significance by having an significant effect on the metabolism and even curative effects of clinically used drugs. Studies on the pharmacogenomics of POR in recent years are summarized as follows.关键词
CYP450氧化还原酶/药物基因组学/细胞色素P450氧化酶/电子供体/基因多态性/药物代谢Key words
Cytochrome P450 oxidoreductase/ Pharmacogenomics/ Cytochrome P450 enzymes/ Electron donor/ Genetic polymorphism/Drug metabolism分类
医药卫生引用本文复制引用
胡蕾,高利臣,卓伟,周宏灏,范岚..CYP450氧化还原酶的药物基因组学研究进展[J].中国临床药理学与治疗学,2012,17(7):820-827,8.基金项目
国家自然科学基金(30801421:30901834) （30801421:30901834）
中南大学基本科研业务重点项目(2010QZZD010) （2010QZZD010）
教育部新世纪优秀人才资助(NCET-11-0509 （）
NCET-10-0843) （）
863计划(2012AA02A517 （）
2012AA02A518) （）
