中国临床药理学与治疗学2012，Vol.17Issue(8)：892-895,4.
靶向临床试验效应估计的偏倚及校正
Bias of treatment effects and its correction in targeted clinical trials
陈林 1刘玉秀 1刘丽霞 1成琪1
作者信息
- 1. 南方医科大学南京临床医学院(南京军区南京总医院),南京210002,江苏
- 折叠
摘要
Abstract
With the completion of the Human Genome Project, we are able to identify the disease-related targets and apply them to disease treatment by developing targeted drugs. Hence, targeted clinical trials are becoming increasingly popular in recent years. However, due to the imperfect diagnostic techniques the patients enrolled in targeted clinical trials with positive result might not all truly have the targets. To include patients with false positive results would result in the bias of treatment effects. This paper analyses the influence of the accuracy of di-
agnostic method in targeted clinical trials and figures out the bias of treatment effects. Then a new statistical method which incorporated EM algorithm and parametric bootstrap would be introduced to give an unbiased estimation of the effect size. The method provides an adequate methodological support for the targeted clinical
trials.关键词
靶向临床试验/偏倚/EM算法/参数Bootstrap抽样Key words
Targeted clinical trial/ Bias/ EM
algorithm/ Parametric bootstrap分类
医药卫生引用本文复制引用
陈林,刘玉秀,刘丽霞,成琪..靶向临床试验效应估计的偏倚及校正[J].中国临床药理学与治疗学,2012,17(8):892-895,4.
