中国临床药理学与治疗学2012，Vol.17Issue(8)：901-906,6.
中国肾移植患者钙蛋白酶10基因多态性与移植后糖尿病的相关性研究
Calpain10 gene polymorphisms are associated with posttransplantation diabetes mellitus in Chinese renal allograft recipients
摘要
Abstract
AIM: To investigate the association between the CalpainlO gene polymorphism and the risk of PTDM in Chinese renal allograft recipients. METHODS; Three single nucleotide polymorphisms (CAPN10 gene SNP-19, SNP-43, SNP-63) were genotyped in the cohort, which consisted of 97 renal allograft recipients with PTDM (PTDM group) and 301 renal allograft recipients without PTDM ( control group). The genotypes of polymorphisms were performed by allele specific polymerase chain reaction ( ASPCR ) , PCR-restriction fragment length polymorphism (PCR-RFLP). Logistic regression test was used to identify risk factors for PTDM development and calculate the odds ratio, RESULTS: The 11 and 12 genotypes of SNP-19 and the GG genotypes of SNP-43 were more common in patients with PTDM than those without PTDM (F<0. 05). After adjustments for age, sex, body weight and BMI, the effect of genotype remained significant (11 vs 22, OR = 1.502, 95%CI: 1.016-2.347, P = 0.048; 12 vs 22, OR=1. 764, 95%CI: 1.055 - 2.947, P = 0. 030) in SNP-19 and the patients carrying gen otype GG had higher risk comparison with carriers with genotype AA or GA(OR = 2. 190, 95% CI: 1.047 - 3.473, P = 0. 044) in SNP-43. But SNP-63 was not association with PTDM. CONCLUSION; The 1-allele in SNP-19 and GG genotype in SNP-43 of CAPN10 gene are the independent risk factors of PTDM in Chinese renal allograft recipients.关键词
肾移植患者/肾移植术后糖尿病/危险因素/钙蛋白酶10基因/单核苷酸多态性Key words
Renal allograft recipients/ Postt-ransplantation diabetes mellitus/ Risk factor/分类
医药卫生引用本文复制引用
余爱荣,范星,刘慧明,辛华雯..中国肾移植患者钙蛋白酶10基因多态性与移植后糖尿病的相关性研究[J].中国临床药理学与治疗学,2012,17(8):901-906,6.基金项目
湖北省自然科学基金计划资助项目(2009CDB010) （2009CDB010）
