中国临床药理学杂志2012，Vol.28Issue(7)：508-512,5.
莫匹罗星对多重耐药金黄色葡萄球菌体外抗菌活性
Antibacterial activity of mupirocin against multi -resistance Staphylococcus aureus in vitro
李耘 1吕媛 1薛峰 1刘健 1杨维维 1张佳1
作者信息
- 1. 北京大学 第一医院 临床药理研究所,北京 100034
- 折叠
摘要
Abstract
Objective To evaluate the in vitro antibacterial activity of mupirocin and other compounds against clinical isolated Staphylococcus aureus. Method A total of 1007 pathogenic isolates 23 tertiary hospitals from 2007 to 2010 in China were studied. The MICs were determined by the twofold agar dilution method . Results Mupirocin exhibited excellent antibacterial activity against Staphylococcus aureus. The values of MIC50 and MIC90 were 0. 25 , 0. 50 mg · L-1, respectively. Mupirocin resistance rates against Staphylococcus aureus and methicillin - resistance Staphylococcus aureus ( MRSA ) were 0. 6% and 0. 9% , which were the lowest among tested agents. Against triple antibiotic ointment or fusidic acid -resistance trains, mupirocin susceptible rates were about 80%. Mupirocin resistance rates against Staphylococcus aureus isolated from various specimen types were between 0-1.0%, secretion isolated strains' resistance was 0. Conclusion Mupirocin resistance rate against MRSA was lower than other tested topical agents. And show good antibacterial activity against MRSA and other resistance strains. There was no cross - resistance between mupirocin and clinically available antibiotics.关键词
莫匹罗星/金黄色葡萄球菌/体外抗菌活性Key words
mupirocin/ Staphylococcus aureus/ in vitro antibacterial activity分类
医药卫生引用本文复制引用
李耘,吕媛,薛峰,刘健,杨维维,张佳..莫匹罗星对多重耐药金黄色葡萄球菌体外抗菌活性[J].中国临床药理学杂志,2012,28(7):508-512,5.
