中国临床药理学杂志2012，Vol.28Issue(7)：513-515,3.
紫杉醇对血管外膜成纤维细胞MAPK/ERK通路的影响
Effect of paclitaxel on vascular adventitial fibroblasts MAPK/ERK pathway
顾磊科 1袁国裕 1沈凯1
作者信息
- 1. 舟山医院 心内科,浙江 舟山 316000
- 折叠
摘要
Abstract
Objective To study influence of paclitaxel on adventitial fi-broblasts from MAPK/Erk pathway. Methods Adventitial fibrobkst (AF) were prepared from rat aortas using explant technique and cultured for passages, 0,9 nmol · L-1 paclitaxel respectively interventions, used Western Blot methods to respectively detect expression of phosphorylation of ERK1/2 then to compare and analysis. Results Phosphorylation of ERK1/2 expression of 9 nmol · L-1 paclitaxel group was significantly less than thai of 0 nmol · L-1 paclitaxel group. The levels of 9 nmol · L-1 paclitaxel group on ERK1/2 phosphorylation express is 62% of paclitaxel 0 nmol · L-1 group (P<0.05) . Conclusion Pach'taxel can delay of resl-enosis after coronary artery intervention with inhibition vascular adventitial fibroblasts MAPK/ERK path.关键词
紫杉醇/血管外膜/PCI术后再狭窄Key words
paclitaxel/vascular adventitial/ restenosis after percutaneous coronary intervention分类
医药卫生引用本文复制引用
顾磊科,袁国裕,沈凯..紫杉醇对血管外膜成纤维细胞MAPK/ERK通路的影响[J].中国临床药理学杂志,2012,28(7):513-515,3.
