中国临床药理学杂志2012，Vol.28Issue(7)：525-527,3.
水杨酸钠对胰岛素抵抗大鼠肝脏核因子-κB及炎症因子表达的影响
Effects of sodium salicylate on the expressions of NF - KB and inflammatory cytokine in hepatic tissue in insulin resistant rats
摘要
Abstract
Objective To investigate the effects of intravenously infused sodium salicylate on hepatic insulin sensitivity in insulin resistant rats. Methods Overnight - fasted Wistar rats were subject to 7 h iv infusion of either saline or intralipid (IH) with or without salicylate. Hyperinsu-linemic - euglycemic clamp with tracer infusion was performed to assess insulin - induced suppression of endogenous glucose production ( EGP) . The expression of NF - kB , IL - 6, TNF - a and SOCS - 3mRNA in liver were examined. Results Infusion of IH markedly decreased insulin - induced suppression of EGP, which were completely prevented by salicylate co - infusion. Compared with saline group,there were elevated 2-4 times of the levels of IL -6, TNF - a, SOCS -3mRNA in liver in rats with IH,the levels of IL-6, TNF -a, SOCS -3mRNA decreased 35% -55% in sodium salicylate with intralipid group. Conclusion The efficacy of sodium salicylate had a new treatment for FFAs - induced insulin resistances. The effect of increasing insulin sensitivity by salicylate in part may be secondary to suppress the activation of NF - kB and downstream cytokine production in liver.关键词
水杨酸钠/胰岛素抵抗/核因子-κBKey words
sodium salicylate/ insulin resistant/ nuclear factor - kB分类
医药卫生引用本文复制引用
何冰,赵晟,张巍,韩萍..水杨酸钠对胰岛素抵抗大鼠肝脏核因子-κB及炎症因子表达的影响[J].中国临床药理学杂志,2012,28(7):525-527,3.基金项目
辽宁省教育厅基金资助项目(20060999) （20060999）
