中国临床医学2012，Vol.19Issue(3)：213-214,2.
合并多囊卵巢综合征产妇胎盘肥胖相关基因多态性研究
Polymorphism of Fat Mass and Obesity Associated gene in the Placenta Tissues from Patients with Polycystic Ovarian Syndrome
摘要
Abstract
Objective:To study the polymorphism of fat mass and obesity associated gene(FTO) rsl421085 (C/T) in placenta tissues from patients with polycystic ovarian syndrome (PLOS),in order to explore the risk of PCOS and relevant diseases in offspring of PCOS patients. Methods: A total of 28 cases of PCOS and 27 healthy volunteers were enrolled. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RELF) and gene sequencing were used to detect the single nucleotide polymorphism(SNP) of FTO rsl421085 (C/T). Results; The allele frequency of FTO rsl421085 (C/T) was significantly different between study group and control group (P = 0. 0072). The frequency of genotype was significantly different between the two groups (P = 0. 0285). Conclusions; The SNP of FTO rsl421085(C/T) variation rate is significantly increased in PCOS patients. It reveals that the offspring of PCOS women may have higher risk in suffering from PCOS and relevant diseases.关键词
多囊卵巢综合症/肥胖相关基因/妊娠结局/单核苷酸多态性Key words
polycystic ovarian syndrome/Fat mass and obesity associated gene/Pregnant outcome/single nucleotide polymorphisms分类
医药卫生引用本文复制引用
顾金萍,陶俊,范建霞..合并多囊卵巢综合征产妇胎盘肥胖相关基因多态性研究[J].中国临床医学,2012,19(3):213-214,2.基金项目
上海市卫生局科研课题资助(编号:2008024) （编号:2008024）
