中国临床医学2012，Vol.19Issue(3)：215-217,3.
转化生长因子-β1-509基因多态性与绝经后2型糖尿病患者骨密度的关系
Transforming Growth Factor-β1-509 Polymorphism is Associated with Bone Mineral Density in Postmenopausal Patients with Type 2 Diabetes Mellitus
摘要
Abstract
Objective: To explore the distribution of polymorphism of transforming growth factor-betal (TGF-β1) gene in shanghai post-menopausal women with type 2 diabetes mellitus (T2DM),and to investigate the relationship between TGF-β1 genotypes and osteoporosis(OP). Methods: A total of 282 unrelated post-menopausal women of Han nationality in Shanghai region were recruited and divided into three groups. They were OP group (Group OP n = 105),T2DM group (Group T2DM,n = 90) and T2DM + OP group (Group T2DM + OP n = 87). Another 82 healthy post-menopausal women of Han nationality in Shanghai region were also enrolled (Group control n = 82). TGF-pl-509 gene polymorphism as well as hemoglobin A1c (HbA1c) were detected,and the bone mineral density (BMD) in lumbar spine (L2-4) was measured. Results: There was no significant difference in the distribution of allele T and C among Group OP,Group T2DM and Group T2DM + OP. The allele frequency distribution on C and T in subjects with OP (Group OP,Group T2DM + OP) and without OP (Group T2DM,Group control) showed significant difference (P-0. 015). There were no significant differences in the levels of HbAlc among the different genotypes of CC,CT and TT. Conclusions: TGF-β1-509 T allele may be the susceptible gene to OP. The TGF-β1-509 genotypes of T2DM patients of had no correlation with HbAlc.关键词
骨密度/转化生长因子-β1/基因多态性/2型糖尿病/骨质疏松症Key words
Bone density/Transforming growth factor beta-1/Gene polymorphism/Type 2 diabetes/Osteoporosis分类
医药卫生引用本文复制引用
陈珂,王博,张秀珍..转化生长因子-β1-509基因多态性与绝经后2型糖尿病患者骨密度的关系[J].中国临床医学,2012,19(3):215-217,3.基金项目
国家自然科学基金(编号:30872726) （编号:30872726）
