Abstract
Objective:To investigate the thyroid function in premature infants. Methods: A total of 80 infants were included in the study,including 60 premature infants who were divided into three groups according to the gestational age[30-31 weeks of gestational age group(Group 1,n - 20) ;32-34 weeks of gestational age group( Group 2,n = 20) -,35-36 weeks of gestational age group(Group 3,n = 20)],and 20 full-term infants (37-41 weeks of gestational age) as control group . Serum free triiodo-thyronine ( FT3 ),free thyroxine ( FT4 ) and thyroid stimulating hormone (TSH) levels were detected on the 3rd,7th,28th day after birth. Results: In groups of premature infants,serum levels of both FT3 and FT4 firstly decreased and then increased. In contrast,serum levels of both FT3 and FT4 in the control group decreased with time and reached a stable level on the 7th day . The serum levels of FT3 on the third day were (4. 4±1. 17) mmol/L in the control group,(3. 33 ± 0. 98) mmol/ L in group 3,(2. 55 ± 0. 613) mmol/L in group 2 and (1. 79 ± 0. 38) mmol/L in group 1 (P<0. 05); on the 7th day,they were (3. 18 ±1.27) mmol/L,(2. 35 ± 0. 45) mmol/L,(1.69 + 0.39) mmol/L,(1.08 ±0.36) mmol/L,respectively (P<0. 05). Similarly,the serum levels of FT4 in the control group,Group 3,Group 2 and Group 1 on the third day were (27. 54 ± 6. 1) mmol/L,(23.73 ± 4.09) mmol/L,(20. 04 ±3. 14) mmol/L,(16. 33 ±3. 17) mmol/L,respectively (P<0. 05) ; and on the 7 th day,they were (21.81 + 4.84) mmol/L,(16. 78 ±2. 2) mmol/L,(14. 88 ±2. 1) mmol/L and (11.66 + 3.42) mmol/L,respectively (P<0. 05). On the 28th day,although no significant difference was observed between the control group and Group 2,or control group and Group 3,all these three groups still had significantly higher serum levels of FT3 and FT4 than Group 1 (P<0. 01). Serum TSH decreased in all the 4 groups with time. On the third day after birth,the serum levels of TSH were (9. 13 ± 2. 91) in Group 2,(6. 48 ± 3. 46) in Group 3 and (4. 29 ± 1. 59) in the control group,all significantly lower than that in Group 1 (11. 75 ± 3. 67) (P<0. 05). On the 7th day after birth,the serum levels of TSH were(6. 13 ± 2. 76) mU/L in Group 1,(5. 03 ±2. 24) mU/L in Group 2,and both of them were lower than that in the control group[(2. 91 ± 1. 62) mU/L],while no significant difference was observed between that in Group 3 [(3. 1 ± 1. 33) mU/L] and that in the control group. On the 28th day,no significant difference in serum TSH level was observed among all the four groups. Conclusions: The thyroid func-tion of the premature infants is transiently low. The shorter the gestational age,the lower the thyroid function is and the longer the stress reaction is.关键词
早产儿/游离三碘甲状腺原氨酸/游离甲状腺素/促甲状腺素Key words
Premature infants/Free triiodothyronine/Free thyroxine/Thyroid stimulating hormone分类
医药卫生
