中国美容医学2012，Vol.21Issue(9)：1332-1333,2.
透明质酸对创面胶原代谢的影响
The effect of extrinsic hyaluronic acid on collagen metabolism in experimental wound healing
谭新东 1李希军 1叶雪玲1
作者信息
- 1. 武警广东总队医院整形美容中心 广东 广州 510507
- 折叠
摘要
Abstract
Objective By detecting the influence of hydroxyproline on collagen metabolism of wound healing of rabbit ear to investigate the inhibition effect of hyaluronic acid on wound healing. Methods Wound healing model were made on the ears of 18 rabbits. They were randomly divided into 2% HA treated-group (groupA), 1%HA treated-group (groupB) and normal saline treated-group (groupC). The wound healing time and scare formation were observed and recorded. The wound area skin was obtained at different days after operation. Tissue hydroxyproline was detected. Data was analyzed statisticaly. Results The hydroxyproline content in group A and B were lower than group C (P<0.01). The difference between group A and B was also prominent (P<0.05). The wound healing time of group A and B were later than group C, the scars also smaller than group C. Conclusion Hyaluronic acid can inhibit the collagen synthesis, delay the wound healing, reduce the scar formation. The dependence relationship between effect and dosage is notable.关键词
透明质酸/创面愈合/羟脯氨酸Key words
haluronic acid/ wound healing/ hydroxyproline分类
生物科学引用本文复制引用
谭新东,李希军,叶雪玲..透明质酸对创面胶原代谢的影响[J].中国美容医学,2012,21(9):1332-1333,2.
