中国美容医学2012，Vol.21Issue(9)：1334-1336,3.
创愈生肌散对糖尿病大鼠模型慢性创面的治疗作用研究
Investigation of therapeutical effect of Chuangyu Shengji Powder on chronic wound of diabetes rat model
摘要
Abstract
Objective To investigate the therapeutical effect of Chuangyu Shengji Powder on chronic wound of diabetes rat model, which is a new drug based on traditional prescriptions. Methods The present study utilize diabetes animal model on rat to form chronic wound to dectect the therapeutical effect and potential mechanism of Chuang Yu Sheng Ji Powder. Compare the wound healing time of animal model cured by Chuangyu Shengji Powder with that of blank control. Investigate the expression of VEGF, HIF-1a and Ang1, which are closely related to angiopoiesis, in tissue sample of chronic wound by Real time PCR. Results The wound healing time of animals with diabetes treated with Chuangyu Shengji Powder, Recombinant Bovine Basic Fibroblast Growth Factor and blank control were (21.3±2.1)d, (23.2±2.4)d and (26.8±2.8)d respectively,among which the difference was statistically significant (P<0.05). Real time PCR showed that the expression of VEGF, HIF-1a and Ang1 were up-regulated in animals treated with Chuangyu Shengji Powder, compared with animals treated with Recombinant Bovine Basic Fibroblast Growth Factor and blank control (P<0.05). Conclusion The results above showed that Chuangyu Shengji Powder could accelerate chronic wound healing through the upregulation of VEGF-IF-1a and Ang1, which were closely related to angiopoiesis.Ba关键词
创愈生肌散/大鼠/糖尿病/慢性难愈创面Key words
Chuangyu Shengji Powder/ rat/ diabetes/ chronic wound分类
医药卫生引用本文复制引用
张子茜,蒯飞,郭树忠,彭湃..创愈生肌散对糖尿病大鼠模型慢性创面的治疗作用研究[J].中国美容医学,2012,21(9):1334-1336,3.基金项目
国家自然科学基金(编号:30973752) （编号:30973752）
