中国美容医学2012，Vol.21Issue(9)：1360-1362,3.
窄谱中波紫外线对自体黑素细胞移植治疗白癜风疗效影响的研究
The study of the influence of different modalities of narrowband ultraviolet B on the effect of cultured autologous melanocyte transplantation in treating vitiligo
摘要
Abstract
Objective To evaluate the therapeutic effect of transplantation of autologous melanocytes transplantation combined with different modalities of NB-UVB in treating vitiligo. Methods Patients with stable vitiligo were randomly assigned to different study groups according to a continuous selection method over a period of three years.Group A was given 20 times of NB-UVB before transplantation;Group B was given 30 times of NB-UVB after transplantation.Group C was given 20 times of NB-UVB before transplantation as well as 30 times of NB-UVB after transplantation.Group D only received transplantation.AII patients were followed up for at least 6 months. Results Group C responded best.more than 90% repigmentation was achived in 81.3% patients, and 93.8% patients experienced 50% or more repigmentation in this group.The cure rate was 68.5% and 61.9% in Group A and Group B.respectively.The effective rate was 92.6% and 88.9% in Group A and Group B,respectively. Group D showed the poorest results,with the cure rate of 44.6% and the effective rate of 73.2%.A homogeneous skin color was obtained and no scarring or other serious side effects were observed. Conclusion Transplantation of cultured autologous melanocytes is an effective modality for the treatment of stable vitiligo.with the advantage of treating large depigmented area with melanocytes from a small donor site. And in association with NB -UVB can improve the transplantation's effectiveness.especially given NB -UVB both before transplantation and after transplantation.lt is valuable in clinical application.关键词
白癜风/黑素细胞/移植/窄波UVBKey words
vitiligo/ autologous melanocyte culture/ transplantation/ NB-UVB分类
医药卫生引用本文复制引用
张迪敏,许爱娥,尉晓东,洪为松,付丽芳,钱国培..窄谱中波紫外线对自体黑素细胞移植治疗白癜风疗效影响的研究[J].中国美容医学,2012,21(9):1360-1362,3.基金项目
杭州市科技局项目(20070433Q01),浙江省国际科技合作项目(2008C14029) （20070433Q01）
