上皮间质转化与恶性肿瘤的转移和侵袭OA北大核心CSCDCSTPCD
Role of epithelial-mesenchymal transition in cancer invasion and metastasis
上皮细胞间质化(EMT)与恶性肿瘤的局部浸润及远处转移有着非常密切的关系.在EMT过程中,细胞表面上皮标志物E-钙黏蛋白表达下调,间质标志物波形蛋白、N-钙黏蛋白表达上调是其主要标志.本文就恶性肿瘤EMT机制的最新研究进展作一综述.
Epithelial-mesenchymal transition (EMT) is closely related to cancer progression such as local invasion and distal metastases. The down-regulation of epithelial marker (E-cadherins) and up-regulation of mesenchymal markers (vimentin and N-cadherin) in the cell surface is the main feature of EMT process. This paper addresses the recent progress in investigating the mechanism underlying cancer EMT.
陈璐
中南大学湘雅医院普通外科,湖南长沙410008
医药卫生
肿瘤/病因学上皮间质转化,综述文献
Neoplasms/etiol Epitheliai-Mesenchymal Transition Review
《中国普通外科杂志》 2012 (7)
886-892,7
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