中国人兽共患病学报2012，Vol.28Issue(7)：669-673,5.DOI:10.3969/cjz.j.issn.1002-2694.2012.07.005
流感病毒感染p53+/+和p53-/-小鼠肺组织中TLR及其相关基因表达研究
Difference in gene expression of Toll-like receptors and downstream molecules in lungs between p53+/+ and p53-/- mice infected with influenza A virus
摘要
Abstract
To analyze the difference in gene expressions of Toll-like receptors (TLRs) and downstream molecules in lungs in the presence and absence of p53 for exploring mechanism of p53 antiviral activity, p53 + / + and pS3-/- mice were infected with influenza virus. The expressions of TLR family genes and its downstream genes in lungs were detected by oligonu-cleotide microarrays and the data were analyzed by SAS system. We found that TLR8, TLR9 and other genes such as NF-kB, TNF-α. and IFN-α showed a significantly different expression in the infected p53+/+ mice as compared with the infected p53-/- mice. TLRs and downstream genes are involved in p53-mediated antiviral response.关键词
流感病毒/Toll-like receptor/p53Key words
influenza virus/ TLR/ p53分类
农业科技引用本文复制引用
晏文君,史子学,魏建超,邓绪芳,朱紫祥,邵东华,王少辉,李蓓蓓,马志永..流感病毒感染p53+/+和p53-/-小鼠肺组织中TLR及其相关基因表达研究[J].中国人兽共患病学报,2012,28(7):669-673,5.基金项目
转基因生物新品种培育科技重大专项(2009ZX08010-022B)和上海市科委重点项目(10JC1417300) （2009ZX08010-022B）
