中国实用妇科与产科杂志2012，Vol.28Issue(5)：363-365,3.
端粒酶催化亚单位在子宫腺肌病组织中的表达及其意义
Expression of human telomerase reverse transcriptase (hTERT) in adenomyosis tissues
摘要
Abstract
Objective To investigate the expression of Human telomerase reverse transcriptase (hTERT) in eutopic and ectopic endometrial tissues of the research group (adenomvosis group) and the control group (CINfll group) investigate the possible molecular mechanism of the pathopoiesis of adenomyosis. Methods In this study data we collected inpa-tients data between January 2006 and September 2009 at the First Affiliated Hospital of Shanxi Medical University. We selected research group(eutopic endometrium and ectopic endometrium cases)and control group(C.IN]II cases) and compared will) positive expression of hTERT of both groups by tissue microarray technology and immunohistochemistry. Results The expression of hTERT in eutopic and ectopic endometrium was significantly higher than normal endometrium ( P < 0. 05). However, no significant difference was found between diffuse group and localized group of research group (P > 0. 05). The expression of hTERT in proliferative phase endometrial was significantly higher than secretory phase endometrial (P < 0. 05). The expression of hTERT was related to the size of uterus (P < 0. 05 ). The expression of hTERT was unrelated to menstrual changes ( P > 0. 05). Conclusion hTERT in the development of adenomyosis may play an important role in the process.关键词
子宫腺肌病/端粒酶催化亚单位/免疫组化Key words
adenomyosis/ hTERT/ immunohistoehemistry分类
医药卫生引用本文复制引用
张三元,李莉,张杏林..端粒酶催化亚单位在子宫腺肌病组织中的表达及其意义[J].中国实用妇科与产科杂志,2012,28(5):363-365,3.基金项目
山西省科技厅攻关课题(042024-2) （042024-2）
