中国实用内科杂志2012，Vol.32Issue(7)：537-539,3.
脓毒症急性肾损伤危险因素及对预后影响318例分析
Risk factors and prognosis of septic acute kidney injury: a clinical analysis
陈铭铭 1刘一娜 1曹勇 1任志慧 1孙宝山 1马晓春1
作者信息
- 1. 中国医科大学附属第一医院,沈阳110001
- 折叠
摘要
Abstract
Objective To analyze the incidence of septic acute kidney injury and its impact on the prognosis. Methods We did a retrospective study on clinical profiles in patients with sepsis from Intensive Care Unit (1CU) of First Affiliated Hospital of China Medical University between January 1st,2008 and June 30th,2010. Patients were allocated into acute kidney injury and non-acute kidney injury group for further statistical analysis of the risk factors responsible for incidence and death by appling Logistic regression model. Results Of 318 patients with sepsis,) 19 (37.4%) developed acute renal injury, which emerged at a mean time of 2. 4 (range:0 ~ 16) days after admission to ICU and lasted for 7. 8 (range;l ~63) days. Staging based on the lowest creatinine level was categorized accordingly within 24 hours after the onset:stage 1 (risk phase) for 74 cases (62. 2% ) , stage 2 (injury phase) for 17 cases (15. 1%) and stage 3 (faliure phase),17 cases (22. 7% ) .respectively. 60 patients received continuous renal replacement therapy (CRRT) at the mean time of 131.8 (range:l -1008) hours.48 patients (15. 1%) with septic acute kidney injury died,among whom 19 abandoned the treatment. There were 37 patients (31. 1% ) ,32 patients (26. 9% ) and 50 patients (42. 0% ,23 cases declined CRRT) who were noted as having complete recovery,partial recovery and no evidence of recovery, respectively. Disseminated intravascu-lar coagulation (DIC) ,cardiopulmonary resucitation (CPR) and high SOFA score were risk factors of acute kidney inury, whilst hyperlaetacidemia was identified as the risk factor of death. Conclusion Patients in ICU are associated with high morbidity and mortality of septic acute kidney injury. D1C.CPR and high SOFA score may increase the risk of incidence, and hyperlantacidemia may predispose to death in patients with septic acute kidney injury.关键词
脓毒症/急性肾损伤/流行病学/病死率/危险因素Key words
sepsis/ acute kidney injury/ epidemiology/ mortality/ risk factor分类
医药卫生引用本文复制引用
陈铭铭,刘一娜,曹勇,任志慧,孙宝山,马晓春..脓毒症急性肾损伤危险因素及对预后影响318例分析[J].中国实用内科杂志,2012,32(7):537-539,3.
