中国实用内科杂志2012，Vol.32Issue(7)：540-542,3.
华法林对超高龄患者抗凝治疗价值研究
Warfarin for anticoagulantion in patients aged over 80 years:a clinical study
摘要
Abstract
Objective Tu analyse the clinical conditions of anticoagulant therapy using warfarin in patients aged over 80 years for further assessment of clinical indications,efficacy and side effects,thus offering rationale for clinical application. Methods We did a retrospective analysis on the clinical profiles of 31 patients aged over 80 years treated with warfarin anticoagulant therapy in the department of cardiology, First Hospital of Peking University between January 2006 and December 2010. Initiation,dosage for maintenance,monitoring of international ratio (INR) and events of thromboembolism and bleeding were evaluated. Results 93. 55% of patients received warfarin therapy passively. 70. 97% of patients were noted as having INR between 2.0 and 3.0,70. 97% of patients treated with <3 mg/d warfarin achieved ideal control and 41.94% of patients were on maintenance therapy using the initial dosage of 1. 5 mg/d. Ischemic stroke was reported in 2 patients who had INR < 2. 0. Contrarily, INR > 2. 5 was associated with incidence of hemorrhage in 2 patients. Conclusion Given an appropriate INK between 2.0 and 2. 5 for maintenance, warfarin with an initial dosage of 1. 5 mg/d is safe and effective for patients aged over 80 years.关键词
华法林/抗凝治疗/老年患者Key words
warfarin/anticoagulation therapy/elderly patient分类
医药卫生引用本文复制引用
于扬,盛琴慧,丁文惠,霍勇..华法林对超高龄患者抗凝治疗价值研究[J].中国实用内科杂志,2012,32(7):540-542,3.基金项目
教育部高等学校博士学科点专项科研基金(2004000l117) （2004000l117）
