中国实用内科杂志2012，Vol.32Issue(8)：621-625,5.
增加地西他滨剂量治疗高危组骨髓增生异常综合征及急性髓系白血病20例分析
Effect of increased-dose decitabine in patients with high-risk myelodysplastic syndrome and acute myeloid leukemia:an analysis of 20 cases
摘要
Abstract
Objective To assess the efficacy of increased-dose decitabine for the treatment of patients with high-risk myelodysplastic syndrome and acute myeloid leukemia ( MDS/AML). Methods Twenty consecutive patients with high-risk MDS/AML were enrolled from First Affiliated Hospital of Suzhou Medical University between September 2009 and January 2012 and were treated with a 5-day decitabine intravenous injection (20 mg/m2 ,once daily). Additional dose of decitabine was determined based on the proliferation of marrow, progenitor cell counts and proportion of marrow granulose via bone . marrow aspiration in combination with general conditions and adverse reactions. The relapse and response rates were analyzed after a treatment course. Results Both complete remission (CR) + marrow CR rate and overall response rate were 75% (n =4) in patients with high-risk MBS after the initial treatment course. Patients with AML yielded CR + marrow CR rate and overall response rate of 18. 8% (re =3) and 50% (n =8) Respectively. And these figures were 25% (n =4) and 75% (n. = 3) in those who received initial chemotherapy, 16. 7% (n=2) and41.7% (n, = 12) in relapsed/refractory patients. A 2-year cumulative survival rate of 42% was reported. Conclusion Increased-dose decitabine may be administered in patients with high-risk MDS/AML in a safe fashion. The fact that single treatment course results in high remission rate remains to be explored.关键词
骨髓增生异常综合征/白血病,髓系,急注/复发难治/地西他滨/去甲基化Key words
myelodysplastic syndrome/ acute myeloid leukemia/ relapsed/refractory/ decitabine/ demethylation分类
医药卫生引用本文复制引用
吴倩,沈益民,陈峰,胡晓慧,金松,张旭辉,何广胜,吴德沛,孙爱宁,仇惠英,金正明,苗瞄,唐晓文,韩悦..增加地西他滨剂量治疗高危组骨髓增生异常综合征及急性髓系白血病20例分析[J].中国实用内科杂志,2012,32(8):621-625,5.基金项目
国家科技支撑计划(2008BAI61B02) （2008BAI61B02）
国家科技重大专项课题(2008ZX09312-026) （2008ZX09312-026）
江苏省高校优势学科建设工程资助项目 （）
江苏省高校自然科学研究项目(09KJB3200l5) （09KJB3200l5）
江苏省临床医学中心(ZX201102) （ZX201102）
江苏省青年科技创新人才基金(BK2004424) （BK2004424）
苏州市社会发展及医药项目(SS08024) （SS08024）
江苏省医学重点人才(H201126) （H201126）
