中国现代手术学杂志2012，Vol.16Issue(2)：119-121,3.
硝酸甘油联合盐酸替罗非班治疗经皮冠状动脉介入术发生无复流现象时的临床疗效研究
Research on the Clinical Outcomes of Nitroglyceride and Tirofiban Hydrochloride in No-reflow Patients after PCI
朱新林 1杨德辉 1谭兵 1彭一星 1徐勇刚1
作者信息
- 1. 中国人民解放军第163中心医院心血管内科,长沙410003
- 折叠
摘要
Abstract
Objective To evaluate the effects of nitroglyceride and tirofiban hydrochloride, a platelet GP II b/ III a receptor antagonist, on the TIMI blood flow for no-reflow patients after percutaneous coronary intervention ( PCI). Methods From January 2005 to October 2011, 40 patients in our hospital with the symptoms of no-reflow after PCI, were randomly divided into two groups. Croup A: took an intracoronary injection of nitroglyceride of 200 ~300μg immediately when no-reflow, and if it was not effective, took an intracoronary injection of tirofiban 5 μg/kg instantly (named as Group A + B). Group B: took an intracoronary injection of tirofiban 5 μg/kg immediately when no-reflow, and if it was not effective, took an intracoronary injection of nitroglyceride 200 ~ 300μg instantly (named as Group B + A). Results The reflow ratio in Group B was better than Group A (P < 0.01). Both of Group A + B and Group B + A could restore the TIMI III forward flow. And each of the combined therapy got better blood flow than the used of the drug alone (P >0. 05). Conclusion Combined intracoronary injection of nitroglyceride and tirofiban on no-reflow patients after PCI can obviously improve the TIMI flow and reduce the occurrence rate of adverse cardiovascular events (MACE), thus may be effective for the myocardial reperfusion, cardiac function and clinical outcomes.
关键词
硝酸甘油/替罗非班/经皮冠状动脉介入术Key words
nitroglycerin/ tirofiban/ percutaneous coronary intervention分类
医药卫生引用本文复制引用
朱新林,杨德辉,谭兵,彭一星,徐勇刚..硝酸甘油联合盐酸替罗非班治疗经皮冠状动脉介入术发生无复流现象时的临床疗效研究[J].中国现代手术学杂志,2012,16(2):119-121,3.
