中国畜牧兽医2012，Vol.39Issue(7)：108-112,5.
伊维菌素小单室脂质体工艺配方优化及质量分析
Optimizing Process and Formula and Analyzing Quality for IvermectinSingle Unilamellar Vesicles
摘要
Abstract
To obtain high entrapment rate of ivermectin single unilamellar vesicles. The study was aim to optimizing preparation process of ivermectin single unilamellar vesicles; we had selected some factors such as ultrasonic frequency, ultrasonic time, mass ratio of lecithin to cholesterol and mass ratio of ivermectin to lecithin to design orthogonal test Ls (27) , and we used RP-HPLC to determine the entrapment rate of ivermectin single unilamellar vesicles under every combination of process and formula. The results showed the optimal process and formula combination of ivermectin single unilamellar vesicles were as follows; the ultrasonic frequency was 200 kHz, the ultrasonic time was 6 minutes and the mass ratio of ivermectin to lecithin was 1: 10. We have obtained high qualitative ivermectin single unilamellar vesicles by optimization, the loading rate reach (92. 35± 0. 61)% ,the quality of drug is fine, the preparation process are simple and feasible.关键词
伊维菌素/小单室脂质体/制剂技术/质量分析/正交试验Key words
ivermectin/ single unilamellar vesicles/ prescription and preparation technology/ quality analyzing/ orthogonal test分类
农业科技引用本文复制引用
何书海,巴桑旺堆,佘永新..伊维菌素小单室脂质体工艺配方优化及质量分析[J].中国畜牧兽医,2012,39(7):108-112,5.基金项目
西藏自治区科技厅重点项目(NO10-1). （NO10-1）
