中国畜牧兽医2012，Vol.39Issue(8)：142-145,4.
钼暴露对雌性小鼠肾脏脂质过氧化损伤及Smac蛋白表达的影响
Effect of Molybdenum on the Lipid Peroxidation Injury and Smac Protein Expression of Kidney in Famale Mice
摘要
Abstract
To investigate the effect of molybdenum on the lipid peroxidation injury and Smac protein expression of kidney in famale mice. Selected sixty 35-day-old female Kunming mice were randomly divided into 3 groups (control group, molybdenum group I , molybdenum groupⅡ ). Three groups were treated with drinking water added with 0, 200, 400 mg/L molybdenum (Mo6+ ), respectively. On the 90th days of experiment, the SOD activity and MDA contends were measured, the expression of Smac protein were examined immunohistochemically in kidney tissue. The results showed that the SOD activity was lower in molybdenum group I than that of the control group(P<0. 05), the SOD activity was lower significantly in molybdenum group Ⅱ than that of the control group(P<0. 01) ; the MDA contends was higher in molybdenum group Ⅱ than that of the control group in kidney tissue(P<0. 05) ; The expression of Smac of renal cortex was higher significantly in molybdenum group than that of the control group (P<0. 01). The results indicated that molybdenum may cause renal lipid peroxidation injury and promote expression of Smac protein in kidney tissue.关键词
钼/肾脏/脂质过氧化损伤/Smac蛋白/小鼠Key words
moybdenum/kidney/lipid peroxidation injury/Smac protein/mice分类
农业科技引用本文复制引用
林霖,李勤凡,汪纪仓,王宏伟,张才,杨自军..钼暴露对雌性小鼠肾脏脂质过氧化损伤及Smac蛋白表达的影响[J].中国畜牧兽医,2012,39(8):142-145,4.基金项目
国家自然科学基金资助项目(31040081) （31040081）
河南科技大学基金资助项目(08ZY017). （08ZY017）
