中国药房2012，Vol.23Issue(20)：1905-1907,3.DOI:10.6039/j.issn.1001-0408.2012.20.33
磷霉素致不良反应124例文献分析
Literature Analysis of 124 Cases of Fosfomycin-induced ADR
刘金永 1孙增先 1张骞峰 1周金玉 1高山1
作者信息
- 1. 连云港市第一人民医院临床药学研究中心,江苏连云港222002
- 折叠
摘要
Abstract
OBJECTIVE: To explore the general regularity and characteristics of adverse drug reactions (ADR) induced by fos-fomycin, and to provide reference for rational safe use of drugs in the clinic. METHODS: Using fosfomycin as key word. CNK1 and Wangfang database were searched. A total of 99 literatures about fosfomycin-induced ADR were collected, involving 124 cases. The data were analyzed retrospectively in respect of patients' gender, age, allergy history, primary disease, medication, ADR on-set time, types and clinical manifestation of ADR, evaluation and outcome. RESULTS: There was no significant difference in patients' gender and age of 124 fosfomycin-induced ADR cases (P>0.05). 37 cases had drug and food allergy history, accounting for 49.33% (75 patients had exact record of allergy history). 121 cases (97.58%) were given fosfomycin intravenously; the most of cases were anaphylactic shock (42 cases, 33.87%), followed by lesion of skin and its appendants (28 cases, 22.58%). The earliest ADR occurred the moment after intravenous dripping while the latest occurred in 5 days after administration. Most of ADR cases recovered when drug withdrawal or treatment were taken. However, there were 8 cases of death. CONCLUSION: ADRs induced by fosfomycin have many kinds of clinical manifestations with some death cases. Clinical doctors and pharmacists should pay more attention to the dangers of ADRs induced by fosfomycin.关键词
磷霉素/不良反应/文献分析Key words
Fosfomycin/ Adverse drug reactions/ Literature analysis
分类
医药卫生引用本文复制引用
刘金永,孙增先,张骞峰,周金玉,高山..磷霉素致不良反应124例文献分析[J].中国药房,2012,23(20):1905-1907,3.
