中国药房2012，Vol.23Issue(27)：2504-2505,2.DOI:10.6039/j.issn.1001-0408.2012.27.03
通脉糖眼明胶囊对糖尿病视网膜病变模型大鼠的保护作用研究
The Tratement Observation of Tongmaitangyanming Capsule to the Diabetic Retinopathy Rat Model
摘要
Abstract
OBJECTIVE: To establish the protective effect of Tongmaitangyanming (TMTYM) capsule on diabetic retinopathy (DR) model rat. METHODS: DR rat model was established by intraperitoneal injection of streptozotocin (STZ.50 mg·kg-1). The model rats were divided into 6 groups, I.e. Blank control group, model group, Anduoming group (0.05 g·kg-1) and TMTYM capsule high-dose, medium-dose and low-dose groups (2.0, 1.0, 0.5 g·kg-1). They were given medicines intragastrically once a day for consecutive 3 months. The changes of fasting blood glucose, glycosylated hemoglobin (HbAlc)content, whole blood viscosity (low shear) and plasma viscosity were observed in rats. RESULTS:Compared with model group,the fasting blood glucose,HbAlc content in TMTYM capsule high-dose group and medium-dose group were lowered significantly(P<0.01). The Plasma viscosity in TMTYM capsule high-dose group ,medium-dose group and low-dose group were lowered significantly(P<0.01).The hematocrit in TMTYM low-dose group was lowered significantly(P<0.05).CONCLUSION: TMTYM capsule can control the blood glucose levels in DR rats, reduce blood viscosity and improve the blood supply of microcirculation so as to delay the development of DR.关键词
通脉糖眼明胶囊/糖尿病视网膜病变/空腹血糖/糖化血红蛋白/血液流变学Key words
Tongmaitangyanming capsule/ Diabetic retinopathy/ Fasting blood glucose/ Glycosylated hemoglobin/ Hemorheol-ogy分类
医药卫生引用本文复制引用
朴春梅,蒋玲,屈相玲,周训蓉,李玲,王翠茹..通脉糖眼明胶囊对糖尿病视网膜病变模型大鼠的保护作用研究[J].中国药房,2012,23(27):2504-2505,2.基金项目
贵州省科学技术计划课题(黔科合中药字[2010]LKZ7014号) （黔科合中药字[2010]LKZ7014号）
